EME VHH and cyclic peptide library
Library diversity: ：１０１２−１４
EME VHH library
（PDB ID: 1l3V）
Features of EME VHH library
【VHH Naïve library】
Prepared from B-cell of Alpaca(Lama pacos)
Containing various length of complementarity
determining regions (CDRs)
> Having thermal stability to withstand heat treatment above 80℃
“VHH artificial library”
VHH antibody shows the same degree (nM order) of antigen affinity as lgG.
Comparison of characteristics of lgG antibody and VHH antibody
|Conventional antibody (lgG)（IgG）||VHH antibody|
|Production by microorganisms||difficult||Easy|
|Refolding from denaturing condition||Impossible||Easy|
|Thermal stability||Low||Very high|
|Acquiring neutralizing antibody||Difficult||Easy|
EME Cyclic Peptide Libraries
EME Cyclic Peptide
EME cyclic peptide libraries are…
- available to be cyclized between cysteineresidues near both ends with various kinds of crosslinking agents.
- available to be prepared with non-natural amino acids composition in random region.
- containing the random amino acid region of 6to 30 amino acids